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Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice

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Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice

Yo Oishi, Qi Xu,

Nature Communications 8, Article number: 734 (2017)
doi:10.1038/s41467-017-00781-4

Motivation ,Neural circuits ,Non-REM sleep ,Sleep ,Slow-wave sleep


 Abstract
  Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep–wake behaviour; however, the precise circuit mechanisms underlying their effects on sleep control are unknown. Previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (NAc), a brain area critical for reinforcement and reward. Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A2A receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep. Chemogenetic inhibition of the NAc indirect pathway neurons prevents the sleep induction, but does not affect the homoeostatic sleep rebound. In addition, motivational stimuli inhibit the activity of ventral pallidum-projecting NAc indirect pathway neurons and suppress sleep. Our findings reveal a prominent contribution of this indirect pathway to sleep control associated with motivation.


題名：マウスの徐波睡眠は側坐核コア部に存在する一群のニューロンにより制御される
　睡眠制御は、2プロセスモデル、すなわち恒常性の制御および日周過程を定める主要な睡眠調節因子として広く受け入れられた概念によって生じている。認知的および感情的要因も睡眠 - 覚醒行動に影響する。しかしながら、睡眠制御に対するそれらの影響の根底にある正確な回路メカニズムは未知である。これまでの研究は、アデノシンが補強と報酬にとって重要な脳領域である側坐核（NAc）における行動的覚醒に影響する役割を有することを示唆している。ここでは、NAcのコア領域における興奮性アデノシンA2A受容体発現間接経路ニューロンの化学的または光発生活性化が、徐波睡眠を強く誘発することを示す。 NAc間接的経路ニューロンの化学的阻害は、睡眠誘導を妨げるが、ホモ恒常性睡眠リバウンドに影響しない。さらに、動機づけ刺激は、腹側隆起性NAc間接的経路ニューロンの活動を阻害し、睡眠を抑制する。私たちの知見は、この間接的な経路がモチベーションに関連した睡眠管理への著しい貢献を明らかにしている。


コメント:これは自分の研究関連というよりは、興味。やる気が出ると目がさえる。非常に身近なテーマであり、なるほどと言う結果。経験的にも、モチベーションと睡眠は関係あるだろう事は頷ける。側坐核との関連は非常に面白い。やりたい事があっても睡眠に負けてしまうのなら、まだモチベーションが上がりきっていない？？これをやりたい！と没頭してしまう興味関心毎なら眠気に負ける事は無くなるか。自分のやる事に義務感を持つのではなく、やはり好きになる事、やる気になる事が大事なのだろう。そして好きになる、やる気になるにはそもそも行動も不可欠。本研究の成果を自分なりに日常生活に落とし込みたいところ。







参考:https://research-er.jp/articles/view/63834




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